الصف :الثاني عشر - العام الدراسي :2015/2016


Human Beings are without any doubt the most complex organisms on the planet Earth. Nevertheless, like all the other organisms, they are formed of billions of microscopic units called cells. Each cell has its own identity, and each group of similar cells gather forming a tissue in order to accomplish a certain job. When several tissues work together then we have an organ, such as the stomach or the kidney. Nevertheless, one organ cannot finish its work by its own, so each couple of organs integrate together to do a more complicated function, and this is called an organ system. We have ten organ systems in our body, each with a complex function that guarantees the continuousness of life[1]. One of these functions is balance development and coordination. This function is done by several anatomical structures including: the nervous system, especially the cerebellum, the vestibular system, and the somatosensory system. However, the cerebellum and the spine integrate and coordinate between the vestibular and somatosensory systems. When one of these structures is damaged or severely affected, the function they preform will subsequently be affected as well. The condition where we have a poor coordination or balance is called “Ataxia”. This disorder can be divided into several groups according to the structure affected or damaged. But still, researches argue about the types or groups of Ataxia. Some researchers say that Ataxia has two types: Sensory Ataxia and Cerebellar Ataxia. To others, there are three types: Sensory, Cerebellar and Vestibular Ataxia. Moreover, some other claim that Frontal Ataxia is a forth type [2]. However, the symptoms of two or more Ataxia types may occur, this is called Mixed Ataxia.

   In this research, we are going to study this disorder, namely the one in the cerebellum through these main questions:

  • What is the Ataxia?
  • What are the main causes of the Ataxia?
  • Are there different types of Ataxia?
  • How can we diagnose it through its symptoms?
  • What are the treatments?
  • Is there a cure?

Several studies argue about the efficiency of Nicotinamide (Vitamin B3) towards the treatment of Friedreich’s Ataxia.

  • Would the Nicotinamide really be a cure for Friedreich’s Ataxia in the future?
  • What are the approaches of these studies?

All of these questions will be answered at the end of this research.

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    96

    The Effect of Nicotinamide in Patients with Friedreich’s Ataxia

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